Immunosuppressive effect of murine cytomegalovirus

Effect of ribavirin on murine cytomegalovirus infection.

Ribavirin (1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide), a new synthetic nucleoside, inhibited murine cytomegalovirus in cell culture. This was shown by the inhibition of viral cytopathic effect and plaque formation, as well as reduction in the yield of virus. Despite this in vitro antiviral effect, ribavirin did not protect mice from mortality produced by a high inoculum of cytomegalov...

Immunosuppressive agents and cytomegalovirus infection.

Cytomegalovirus (CMV) infection is the major infectious complication observed after organ transplantation. As rejection episodes always occur in allograft-transplanted recipients, various kinds of immunosuppressive agents are used to control such rejection episodes. Among the commonly used immunosuppressive agents, anti-pan-T cell polyclonal and monoclonal antibody are known to increase the ris...

Cytomegalovirus infection complicating immunosuppressive treatment.

Two case reports in this issue of the Journal describe remarkably similar clinical presentations. The patients (a 37 year old woman1 with systemic lupus erythematosus and a 49 year old man2 with glomerulonephritis and pulmonary haemorrhage) presented with lung involvement which improved after immunosuppressive therapy was instituted. The patients were maintaoned on lower doses of immunosuppress...

Characterization of Murine Cytomegalovirus

Effect of Cytomegalovirus Recombinant Phosphoprotein 150 (pp150) on Function and Maturation of Murine Dendritic Cells: an In-Vitro Study

Background: Tegument protein pp150 of cytomegaloviruses (CMVs) plays a vital role in all stages of viral life cycle, representing the most important tegument protein candidate for HCMV treatment. However, the exact role of pp150 in immune regulation is yet to be elucidated. Objective: To examine the effects of pp150 on the maturity and function of muri...